Epoxomicin

Epoxomicin

General description

Epoxomicin is a linear peptide consisting of a threonine or serine residue with α ′, β′-epoxyketone derived from leucine or a γ, δ-dehydroleucine. It is a natural product isolated from Actinomyces sp., And is a potent, selective, and irreversible cell-permeable proteasome inhibitor.

Request

Epoxomicin has been used:

  • as an inhibitor of the ubiquitin-proteasome system (UPS) in pheochromocytoma PC12 cells.
  • as a proteasome inhibitor in mammary epithelial MCF-10A cells.
  • as a proteasome inhibitor in chymotryptic assays in cardiomyocytes.

Packaging: 50 μg in a glass bottle

Biochemical / Physiological Actions

Epoxomicin binds covalently to the catalytic subunits of the proteasome. It forms an adduct with target proteins. Inhibits the chymotrypsin-like activity of the proteasome. Epoxomicin also inhibits activated B-cell light chain enhancer nuclear factor κ (NF-κB) mediated by the proinflammatory signaling pathway. It is also a powerful anti-tumor and anti-inflammatory agent. Epoxomicin, a natural product isolated from Actinomyces sp., Is a potent, selective, and irreversible cell-permeable proteasome inhibitor.

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